Endocrine Abstracts

Introduction: Pseudohypoparathyroidism (PHP) type 1a is a genetic disorder associated primarily with resistance to parathyroid hormone (PTH). Its pathogenesis has been linked to dysfunctional G-protein-mediated signaling. Since the G unit is an ubiquitary protein, its mutation can lead to variable hormonal dysfunction. In this context we report the case of a patient followed in our department for multihormone resistance.Case report: A 9 years old boy, bo...

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage when one or more hormonal insufficiencies are already installed. This study aims to describe the clinical and biological features of hypopituitarism associated with somatotropic adenomas.Patients and Methods : We conducted a retrospective study at the Endocrinology department of Hedi Chaker University...

Introduction: Pituitary adenomas are the most frequent sellar tumors in adults. Depending on their hormonal profile in vivo and on immunohistochemistry, they present different clinical profiles and progression outcomes. Thus, we report a case of an FSH-secreting pituitary adenoma.Observation: The patient SG is 63 years old. He complained of intermittent headaches associated with a progressive decrease in visual acuity. Ophthalmological examinati...

Introduction: Turner syndrome (TS) is a genetic condition, that results from the complete or partial loss of the second X chromosome in phenotypic females. Typically, patients with TS have growth retardation, altered pubertal development and facial dysmorphism. It’s also associated with other comorbidities.Aim: Here we report a rather rare finding which is the association of TS and Rokitansky-Küster Hauser (RKH) and we discuss the possible ethi...

Introduction: Hashimoto’s encephalopathy (HE) is characterised by the combination of clinical signs of encephalitis and autoimmune thyroiditis with elevated levels of antithyroid antibodies (ATA). It is a rare condition and its etiopathogenesis is still poorly understood.Observation: we present a 33-year-old female patient who was hospitalized for gait disorders. The diagnosis of a chronic cerebellar syndrome related to Hashimoto’s encephalitis...

Introduction: Pheochromocytoma occurs in 0.1–5.7% of patients with Neurofibromatosis type 1(NF1). We report two cases of adrenal pheochromocytoma in patients with NF1.Observation: A 46 year-old male was admitted to our department for further examinations of an adrenal mass. The CT-scan showed two well-defined right adrenal masses measuring each 128×87×86 mm and 60×52×37 mm with central necrosis and calcifications in the biggest o...

Introduction:: The association of breast cancer and neuroendocrine tumours, in particular pheochromocytoma, is rarely described in the literature. We report a case in a particular context.Observation: This is a 53-year-old patient treated with 6 courses of chemotherapy for T2N3cM0 infiltrating breast carcinoma. She was admitted to our endocrinology department for exploration of a left adrenal incidentaloma, objectified in the extension assessment, measur...

Introduction: The pituitary stalk is the target of various congenital or acquired pathologies. In this context we report a cohort of 28 patients with pathology of the pituitary stalk to analyze their clinical, hormonal and radiological characteristics.Results: The average age of our patients was 28 years with extremes ranging from (15 to 64); Male dominance was noted in 60% of cases. The reason for consultation was either a staturo delay or a pubertal de...

Introduction: Infertility is a classic consequence of prolactinoma in women. The treatment of hyperprolactinemia allows the restoration of ovulatory cycles and therefore of fertility in 80–90% of cases.Methods and materials: The study is a retrospective cohort study done over 17 years from 2000 to 2017. It includes 77 cases of prolactinomas among which 12 women had one or more pregnancies after the diagnosis of prolactinoma.Re...

Introduction: Autoimmune polyglandular syndrome (APS) is an autoimmune disorder that affects many endocrine glands. Until now four categories of APS are identified: APS-I includes at least two out of: mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. APS-II, the most frequent, comprises of Addison’s disease, autoimmune thyroid disease and/or type 1 diabetes. APS-III is defined by the presence of autoimmune thyroid disease and other autoimmune disor...